Messrs. E.J. Sanford & Co. (1872)
Gentleman: About twenty years ago I had my ankle mashed by the fall of my horse. Since that time until recently, I have suffered very much from pain, swelling and weakness in it, which has rendered plowing and farm work by me almost impossible. A few weeks since I was induced by a friend to try “Dr Hart’s Greatest Relief,” and by the use of it ten days my ankle was made sound and well, William MEANS; Clover Hill, Sixth District, Blount Co. (page 3, col 1)
Source: Cleveland Banner (Cleveland, TN); 26 April 1872. Available online at Google News Archive