Isaac N. Guthrie, one of Sumner County's most extensive farmers and stock raisers, residing in the Fourth District, is a son of James and Elizabeth (GIBBS) Guthrie, and was born in Franklin County, Ky., in 1810, being the fifth born of eleven children and the only one living. His father was born in Virginia in 1779 and died in 1840. His grandfather, Thomas Guthrie, was a native of Virginia and a volunteer in the war of independence. He moved to Woodford County, Ky., in 1782, where he died in 1837. Our subject's father received but a limited education. He was married in 1802, and was a farmer and hotel-keeper, and a man of considerable means. The mother was born in Virginia in 1780 and died in 1859. Both parents were members of the Baptist Church. Isaac N. Guthrie was raised and educated at home, and July 6, 1832, he married Miss Mary BEAUCHAMP, of Spencer County, Ky. Five children were the issue of this union, four sons living: James I., Isaac N., Jr., Nathan N. and Henry Clay, all of whom served in the Confederate Army. Mrs. Guthrie died September 15, 1844, and May 8, 1845, he married Miss Martha A. MONTGOMERY, of Shelby County, Ky. Eight children were born to this marriage; three sons and three daughters living: George N. (of Gallatin), Elizabeth J. (wife of Jacob LIVAR), Emma L. (wife of Legrand SCOTT, of Davidson County), Frank, Willie M. and Mary Beauchamp. Mrs. Guthrie died July 30, 1877, and March 25, 1879, he married Mrs. Margaret E. TAYLOR, a daughter of Thomas and Margrie HARDIN, of Logan County, Ky., Mrs. Guthrie was born in that county in 1832. He father was a native of Casswell County, N.C., and her mother of Baltimore, Md. Mr. Guthrie first located in Shelby County, Ky., where he was a merchant for many years and also a farmer. In 1848 he moved to Sumner County, and continued to merchandise at Gallatin in connection with farming until 1860, and since then has given all of his time to farming and breeding thoroughbred shorthorn cattle, Southdown sheep, Berkshire hogs and Percheron trotting horses, and has met with great success. Mr. Guthrie owned at one time 583 acres of valuable land in Sumner County, but his farm now contains only 350 acres, having given some to his children. He has a handsome brick residence on his farm, four miles west of Gallatin, on the Louisville & Nashville Railroad. In 1865 Mr. Guthrie was elected magistrate, and held the office for twelve years. He was formerly a Whig, and cast his first presidential vote for Henry Clay in 1832. Mr. Guthrie has been a prominent Mason for many years, and was also clerk and treasurer of the Baptist Church at Gallatin, Tenn. Mrs. Guthrie belongs to the Methodist Episcopal South. Mr. Guthrie was appointed by President Jackson postmaster at Shelbyville, Ky. He is one of the most influential citizens of the county, and has been active in all measures that would promote the interests of his town and country.